Category Archives: Diabetes

Apple reportedly developing non-invasive glucose monitor

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CNBC’s Christina Farr has reported that Apple has been quietly developing a non-invasive, sensor-based glucose monitor.  The technology has apparently advanced to the trial stage.

Diabetes has become a global epidemic.  Continuous monitoring, automatic insulin delivery, and the “artificial pancreas” are significant steps forward, meant to control the disease, and avoid its debilitating side effects.  While some systems consist of micro-needles just below the skin, to date, none are totally non-invasive.

The ideal solution would be the use of the Apple Watch and other fitness/lifestyle trackers to control behavior to the point that the disease is avoided entirely.  However, if diagnosed, a non-invasive glucose sensor would transform the daily life of diabetics.


Join ApplySci at Wearable Tech + Digital Health + NeuroTech Boston – Featuring: Joi Ito, Ed Boyden, Roz Picard, George Church, Tom Insel, John Rogers, Jamshid Ghajar, Phillip Alvelda and Nathan Intrator – September 19, 2017 at the MIT Media Lab

Consumer wearable + medical monitor track exercise’s impact on glucose

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Consumer wearables can complement medical devices by integrating activity data into a disease management strategy.

Fitbit movement data will now be used with a Medtronic diabetes management tool, with the goal of users predicting the impact of exercise on glucose levels.

Diabetics can monitor glucose with Medtronic’s iPro2 system continuously for 6 days. Fitbit data will integrated into the  iPro2 myLog app. Users will no longer need to log daily activity on paper, and the information is easily shared with physicians and caregivers.

ApplySci’s 6th  Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Sky Christopherson – Marcus Weldon – Krishna Shenoy – Karl Deisseroth – Shahin Farshchi – Casper de Clercq – Mary Lou Jepsen – Vivek Wadhwa – Dirk Schapeler – Miguel Nicolelis

 

Diabetic retinopathy-detecting algorithm for remote diagnosis

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Google has developed an algorithm which it claims is capable of detecting diabetic retinopathy in photographs.  The goal is to improve the quality and availability of screening for, and early detection of,  the common and debilitating condition.

Typically, highly trained specialists are required to examine photos, to detect the lesions that indicate bleeding and fluid leakage in the eye. This obviously makes screening difficult in poor and remote locations.

Google developed a dataset of 128,000 images, each evaluated by 3-7 specially-trained doctors, which trained  a neural network to detect referable diabetic retinopathy.  Performance was tested on two clinical validation sets of 12,000 images. The majority decision of a panel 7 or 8 ophthalmologists served as the reference standard. The results showed that the accuracy of the  Google  algorithm was equal to that of the physicians.


ApplySci’s 6th   Wearable Tech + Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Krishna Shenoy – Karl Deisseroth – Shahin Farshchi – Casper de Clercq – Mary Lou Jepsen – Vivek Wadhwa – Dirk Schapeler – Miguel Nicolelis

Sensor sock detects diabetic inflammation, sends alerts

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Siren Care‘s real-time temperature sensing smart sock is meant to detect foot inflammation in diabetics.  The goal is early notification to prevent (difficult to heal) sores and other symptoms of the disease, which can lead to extreme complications.

Data is stored in the fabric  and in the cloud.  An app sends alerts when a temperature event occurs. The washable sock is meant to last for 6 months, as is its battery, which does not require charging.


ApplySci’s 6th   Wearable Tech + Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Krishna Shenoy – Karl Deisseroth – Shahin Farshchi – Casper de Clercq – Mary Lou Jepsen – Vivek Wadhwa – Dirk Schapeler – Miguel Nicolelis

ApplySci is delighted to welcome the Bayer LifeScience iHUB as a sponsor of Digital Health + NeuroTech at Stanford.

Fully transparent, glucose monitoring contact lens

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Oregon State’s Greg Herman has developed a transparent sensor to monitor glucose (via tears) in a contact lens.  The device could also be used to control insulin infusions, by transmitting real-time data to a pump.

Similar technology has been developed by Google, although their lens is not (currently) fully transparent, and Noviosense, which requires a user to insert a device in the lower lid.

Herman believes that the lens sensor could also be used to monitor stress hormones, uric acid, and  ocular pressure in glaucoma.


ApplySci’s 6th   Wearable Tech + Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Mary Lou Jepsen – Vivek Wadhwa – Miguel Nicolelis – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Krishna Shenoy – Karl Deisseroth

Non-invasive tear sensor continuously monitors glucose

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Noviosense is a flexible sensor glucose monitor, worn in a lower eyelid. The wireless, battery-free wearable tracks glucose levels in tears, and continuously sends measurements to one’s phone.

One of three electrodes is coated with an immobilized enzyme, which converts glucose into gluconic acid, leaving the co-enzyme FAD reduced to FADH. An  oxygen molecule oxidizes the co-factor and produces a short lived molecule of hydrogen peroxide, that is converted on the electrode surface to water. This results in an electric current, measured using the other two electrodes. The electrical signal is then converted into a radio frequency signal, transmitted via antenna.

It is possible to connect the sensor to an insulin pump, creating a closed loop system.


ApplySci’s 6th   Wearable Tech + Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Mary Lou Jepsen – Vivek Wadhwa – Miguel Nicolelis – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Krishna Shenoy – Karl Deisseroth

REGISTRATION FEE INCREASES ON NOVEMBER 1, 2016

Sanofi/Verily joint venture to fight diabetes

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Big pharma + big tech/data partnerships continue to proliferate.

Onduo is a Sanofi/Verily joint venture that will use each company’s expertise to help manage diabetes  — Sanofi’s drugs  plus Verily’s software, data analysis, and devices. CEO Josh Riff and has not announced a project pipeline, as they are taking “a thoughtful approach to finding lasting solutions.”

Sutter Health and Allegheny Health Network will  be the first systems to test Onduo solutions.


ApplySci’s 6th   Wearable Tech + Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Mary Lou Jepsen – Vivek Wadhwa – Miguel Nicolelis – Roozbeh Ghaffari – Unity Stoakes

GSK/Verily “biolectronic medicine” partnership for disease management

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Galvani Biolectronics is a Verily/GSK company, created to accelerate the research, development and commercialization of bioelectronic medicines. The goal is to find solutions to manage chronic diseases, such as arthritis, diabetes, and asthma, using  miniaturized electronics.  Implanted devices would  modify electrical signals that pass along nerves, including irregular impulses that occur in illness.

Initial work will focus on developing precision devices for inflammatory, metabolic and endocrine disorders, including type 2 diabetes, where substantial evidence already exists in animal models.

Every major pharmaceutical company (globally) attended  ApplySci’s recent Wearable Tech + Digital Health + NeuroTech conferences in San Francisco and New York.  We believe that partnerships similar to the Verily/GSK venture will proliferate — and that they will improve the lives of those with chronic diseases.


Digital Health + NeuroTech Silicon Valley – February 7-8, 2017 @ Stanford University

“Artificial pancreas” uses sensor + app monitoring system

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University Hospital of Montpellier researchers, led by Eric Renard, are developing a sensor/app “artificial pancreas” system for diabetics.

The sensor continuously monitors glucose.  The data is sent to a phone, where an algorithm calculates insulin needed, and to a pump, which then delivers the correct amount of insulin.

So far, the system has only been tested on 21 patients for 1 month, where the results were promising.  Obviously, much more research is needed. The next stage will involve 240 child and adult patients, who will use the device for 6 months.

Contact lens/eyeglass system monitors blood sugar, dispenses drugs

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Pohang University’s Sae Kwang Han and Do Hee Keum have developed a contact lens/ eyeglass combination  to monitor diabetes and dispense drugs as needed.  The glasses wirelessly power and communicate with the drug-releasing lens, that monitors glucose concentration in tears.  An LED alarm lights up when sugar levels are very high. The lens can be worn for one month.

A user can  tell the eyeglasses to send a drug-releasing signal to the chip with voice commands. A control circuit is being created to automate the process,  deciding independently when medicine is needed. To release drugs, the chip draws on one of ten drug reservoirs chambers that are carved into the hydrogel, and covered with a thin gold electrode membrane. The voltage dissolves the membrane and releases the drug.


Wearable Tech + Digital Health NYC – June 7, 2016 @ the New York Academy of Sciences

NeuroTech NYC – June 8, 2016 @ the New York Academy of Sciences