Category Archives: Skin

3D-bioprinted human skin can replace animal testing, potentially be used in burns

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José Luis Jorcano at Universidad Carlos III de Madrid has developed a 3D bioprinter capable of replicating the structure of skin. The human-like  skin that is produced  includes an epidermal layer that protects against the environment, and a collagen-producing dermis that provides elasticity and strength.

The bioink material  contains human plasma, and  primary human fibroblasts and keratinocytes obtained from biopsies.

Currently, 100 cm2 of the printed skin  is able to be produced in 35 minutes.

ApplySci’s 6th  Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Sky Christopherson – Marcus Weldon – Krishna Shenoy – Karl Deisseroth – Shahin Farshchi – Casper de Clercq – Mary Lou Jepsen – Vivek Wadhwa – Dirk Schapeler – Miguel Nicolelis

Electric fields induce nanoscale deficits to rejuvenate skin

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Harvard and Tel Aviv University researchers have developed a non-invasive tissue stimulation technique, utilizing microsecond-pulsed, high-voltage, non-thermal electric fields, to produce scarless skin rejuvenation.  Already effective in tumor removal and wound disinfection, the technique may revolutionize the treatment of degenerative skin diseases.

Current skin therapies use  physical and chemical methods to affect cells and the extracellular matrix, but induce scarring. Pulsed electric fields only affect the cell membrane, preserving the extracellular matrix architecture and releasing multiple growth factors to spark new cell and tissue growth. By inducing nanoscale defects on the cell membranes, electric fields cause the death of a small number of cells in affected areas. The released growth factors increase the metabolism of the remaining cells, generating new tissue.