Category Archives: Uncategorized

fMRI + EEG used to detect consciousness in ICU patients

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MGH’s  Brian Edlow and colleagues have completed a small study showing the efficacy of using fMRI and EEG in ICU TBI patients to detect consciousness.  Previous research has suggested that up to 40% of conscious patients are misclassified as unconscious.

The goal is to create a more informed care plan, and earlier interventions that could improve outcomes.

16 patients with severe traumatic brain injury at MGH’s ICU were studied. At the start, 8 patients could respond to language, 3 were classified as minimally conscious with no language response, 3 were classified as vegetative, and 2 were in a coma. The study also included a healthy control group 16.

f MRI scans were performed as soon as the subjects were stable. EEG readings were usually taken within 24 hours after the fMRI scan.  Tests were designed to detect a mismatch between their ability to imagine performing a task and their ability to physically express themselves (cognitive motor dissociation.)

Through the study, researchers detected evidence of consciousness in 4 of the 8 patients who were unable to respond to language in bedside exams, including the 3 classified as vegetative. (It was also noted that 25% of the healthy controls had no detectable brain response in a hand-squeeze imagery test.)

The subjects were also exposed to brief recordings of spoken language and music during both fMRI and EEG to detect activity in certain brain regions. Higher-order cortex activity was seen in 2 additional subjects. While higher-order cortical activity doesn’t prove that a patient is conscious, finding a response in those structures could have implications for a patient’s eventual recovery.

A 19 electrode EEG device was used for the study.

Brain health company Neurosteer is attempting to gather similar neural activity data with its continuous, mobile, 3 electrode, EEG wearable.  The company’s CEO, Nathan Intrator, will present this work at ApplySci’s Wearable Tech + Digital Health + Neurotech conference, on September 19th at the MIT Media Lab.


Join ApplySci at Wearable Tech + Digital Health + NeuroTech Boston on September 19, 2017 at the MIT Media Lab – featuring  Joi Ito – Ed Boyden – Roz Picard – George Church – Nathan Intrator –  Tom Insel – John Rogers – Jamshid Ghajar – Phillip Alvelda – Michael Weintraub – Nancy Brown – Steve Kraus – Bill Geary – Mary Lou Jepsen

Registration rates increase Friday, August 18th.


ANNOUNCING WEARABLE TECH + DIGITAL HEALTH + NEUROTECH SILICON VALLEY – FEBRUARY 26 -27, 2018 @ STANFORD UNIVERSITY

Wearable, high resolution, continuous opto-electronic monitoring

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MRI, disrupted.

Mary Lou Jepsen’s background in consumer electronics, computers, TV, VR, wearables, healthcare and software at Google x,  Facebook, and Oculus has led to the creation of Openwater — a company that will enable us to see the inner workings of the body and brain.  At high resolution, continuously.

Using novel opto-electronics, the company aims to replace the functionality of MRI with a wearable.  Applications include the  detection and treatment of cancer, cardiovascular diseases, internal bleeding, and brain diseases, and for communication via thought,  and potentially to upload/download and augment memories, thoughts and emotions.

The technology uses the scattering of the body or the brain to focus infrared light to scan itself, bit by bit, or voxel by voxel. This is enabled by LCDs with pixels small enough to create reconstructive holographic images that neutralize the scattering and enable scanning at MRI resolution and depth, coupled with body-temperature detectors.

These LCDs and detectors line the inside of a ski-hat, bandage or other clothing, and are designed to modulate the interference of intensity and phase in the near infrared regime with the video-rate computer generated holograms integrated with embedded detectors. The brain or body will be able to be scanned systematically or selectively. The system can be used in reverse, to focus light to any area of interest in the body or brain (for tumor treatment.)

Once again, Mary Lou Jepsen is pioneering technology that will transform — and save — lives.  We are honored to include her as a speaker at Wearable Tech + Digital Health + Neurotech Boston, on September 19th at the MIT Media Lab.

Click to view Jepsen’s talk at ApplySci’s  February, 2017 Wearable Tech + Digital Health + Neurotech Silicon Valley conference at Stanford University


Join ApplySci at Wearable Tech + Digital Health + NeuroTech Boston on September 19, 2017 at the MIT Media Lab – featuring  Joi Ito – Ed Boyden – Roz Picard – George Church – Nathan Intrator –  Tom Insel – John Rogers – Jamshid Ghajar – Phillip Alvelda – Michael Weintraub – Nancy Brown – Steve Kraus – Bill Geary – Mary Lou Jepsen – Daniela Rus

Registration rates increase Friday, August 4th.


ANNOUNCING WEARABLE TECH + DIGITAL HEALTH + NEUROTECH SILICON VALLEY – FEBRUARY 26 -27, 2018 @ STANFORD UNIVERSITY

Robotic leg brace helps stroke patients walk

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Toyota’s Welwalk WW-1000 exoskeleton is designed to help those with paralysis on one side of their body walk again. The frame is worn on the affected leg, with a  motor at the knee joint that provides calibrated assistance based on a user’s ability.  Wearers are trained to recover their walking ability over time.

The robotic device is paired with a treadmill and harness that is controlled by medical staff. The  system will be rented to hospitals in Japan for $9000, plus $3200 per month.

The hope is that it will dramatically speed recovery time for stroke patients. The  brace integrates sensors that determine exactly how much support to provide  at any given point, ensuring that patients aren’t over-reliant on support, or rushed before they’re ready to progress.


Join ApplySci at Wearable Tech + Digital Health + NeuroTech Boston on September 19, 2017 at the MIT Media Lab. Featuring Joi Ito – Ed Boyden – Roz Picard – George Church – Tom Insel – John Rogers – Jamshid Ghajar – Phillip Alvelda – Nathan Intrator

Tiny wearable sensor measures blood flow

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Kyocera has developed a tiny optical sensor to measure blood flow volume in subcutaneous tissue, meant to be integrated into a phone or wearable. Potential applications include monitoring stress and preventing dehydration, heat stroke, and altitude sickness.

The device will be used  in/on an ear, finger or forehead, to measure the velocity-driven frequency of reflected light within blood vessels. The  sensor utilizes the relative shift in frequency and the strength of the reflected light  to determine blood-flow volume.

ApplySci’s 6th  Digital Health + NeuroTech Silicon Valley  –  February 7-8 2017 @ Stanford   |   Featuring:   Vinod Khosla – Tom Insel – Zhenan Bao – Phillip Alvelda – Nathan Intrator – John Rogers – Roozbeh Ghaffari –Tarun Wadhwa – Eythor Bender – Unity Stoakes – Mounir Zok – Krishna Shenoy – Karl Deisseroth – Shahin Farshchi – Casper de Clercq – Mary Lou Jepsen – Vivek Wadhwa – Dirk Schapeler – Miguel Nicolelis

 

“Mixed Reality” headset could support surgery, rehab, learning

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Magic Leap has unveiled its “mixed reality” headset, where  virtual objects are integrated into the real world.  In addition to obvious gaming and entertainment applications, the system could be used in healthcare (including in surgery, surgery preparation, and orthopedic rehabilitation) and education.

The company remains vague in its description of its technology, but head and hand tracking functionality appear to have been added.   According to founder Rony Abramovitz, “Magic Leap doesn’t trick the brain. Rather it shoots photons into the eye that stimulate the cones and rods as if the hologram were real, or neurologically true.”

Click to view Magic Leap video.


Wearable Tech + Digital Health NYC – June 7, 2016 @ the New York Academy of Sciences

NeuroTech NYC – June 8, 2016 @ the New York Academy of Sciences

Wrist-worn wearable detects Atrial Fibrillation, sends alerts

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AliveCor is known for its FDA approved mobile EKG, which attaches to a phone or tablet.  The company has just announced  Kardia – an Apple Watch band that, when a sensor is pressed and paired with an app, can provide and accurate EKG, incorporate a user’s spoken symptoms into its analysis, and share data.  AliveCor said that the band and app can detect Atrial Fibrillation, which would be shared with a doctor immediately.

Click to view AliveCor video


Wearable Tech + Digital Health San Francisco – April 5, 2016 @ the Mission Bay Conference Center

NeuroTech San Francisco – April 6, 2016 @ the Mission Bay Conference Center

Wearable Tech + Digital Health NYC – June 7, 2016 @ the New York Academy of Sciences

NeuroTech NYC – June 8, 2016 @ the New York Academy of Sciences

Injectable nanotech device continuously monitors glucose

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Kyungsuk Yum at the University of Texas is developing an internal, nanoscale device to continuously analyze blood sugar.   A near infrared optical biosensor nanotube is injected, and an optical scanner accesses data for constant monitoring .

Current continuous monitoring technology for diabetes requires a tube inserted through the abdomen.  This reads glucose levels in tissue, which is not as accurate as blood reading.  It must be calibrated several times per day, and changed every week.

The traditional glucometer system requires blood-drawing finger pricks throughout  the day.

WEARABLE TECH + DIGITAL HEALTH SAN FRANCISCO – APRIL 5, 2106 @ THE MISSION BAY CONFERENCE CENTER

NEUROTECH SAN FRANCISCO – APRIL 6, 2016 @ THE MISSION BAY CONFERENCE CENTER

WEARABLE TECH + DIGITAL HEALTH NYC – JUNE 7, 2016 @ THE NEW YORK ACADEMY OF SCIENCES

NEUROTECH NYC – JUNE 8, 2016 @ THE NEW YORK ACADEMY OF SCIENCES

Smart airline uniforms improve passenger safety

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easyJet has partnered with CuteCircuit to create sensor embedded crew uniforms to improve passenger safety.

Cabin crew uniforms have shoulder LEDs and illuminated hems to provide lighting. Lapel LEDs display fight numbers, and microphones  in the fabric enable immediate communication.

Engineers’ uniforms have LEDs in  jacket hoods to illuminate work areas, and built in cameras to share photos for assistance.  Integrated air quality sensors and barometers notify workers of environmental issues, and create a city-by-city air quality map for passengers.

WEARABLE TECH + DIGITAL HEALTH SAN FRANCISCO – APRIL 5, 2016 @ THE MISSION BAY CONFERENCE CENTER

NEUROTECH SAN FRANCISCO – APRIL 6, 2016 @ THE MISSION BAY CONFERENCE CENTER

Norwest’s Robert Mittendorff on digital health investing

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Norwest Venture Partners’ Robert Mittendorff participated in ApplySci’s recent Wearable Tech + Digital Health NYC conference.  Here is his interview with StartUp Health’s Steven Krein on digital health investing.

UPCOMING APPLYSCI CONFERENCES:

Wearable Tech + Digital Health San Francisco – April 5, 2016 – Early registration discount ends October 10th

NeuroTech San Francisco – April 6, 2016 – Early registration discount ends October 10th.

Ultra-low-field, portable MRI

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Los Alamos National Laboratory‘s Michelle Espy is developing an ultra-low-field, lightweight MRI system for use on the battlefield and in poor countries.  The device will be simple to transport, set up, and use in non-traditional settings.

Conventional MRI machines use large magnetic fields that align protons in water molecules. Magnetic resonance signals are detected and turned into images. Highly detailed images are created, but the process is complicated and expensive. Espy uses Superconducting Quantum Interference Devices (SQUID) to create quality images with ultra-low-magnetic fields.

The  first generation (battlefield) “b”MRI was built in a large metal housing to shield it from interference.  The team is now surrounding the system with lightweight wire coils in the open environment to compensate the Earth’s magnetic field.  A field compensation system will soon eradicate invading magnetic field signals.

WEARABLE TECH + DIGITAL HEALTH NYC 2015 – JUNE 30 @ NEW YORK ACADEMY OF SCIENCES. REGISTER HERE.